"Activated Translation of HIF-1α mRNA as a Key Mechanism in Oncogenesis of Pancreatic Ductal Adenocarcinoma and Other Malignant Diseases"
نویسندگان
چکیده
Molecular targeted therapies against KRAS mutant pancreatic ductal adenocarcinoma (PDAC) remain insufficient. The most serious causes are supposed to be bypass activation of the PI3K/AKT/mTOR signaling pathway and crosstalk between mTOR hypoxia inducible factor (HIF). This short review is aimed at clarifying involvement activated translation HIF-1α mRNA in oncogenesis PDAC association with CA9 activation.
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific and Technical Research
سال: 2023
ISSN: ['2574-1241']
DOI: https://doi.org/10.26717/bjstr.2023.51.008156